Michael Chopp Selected Research

Sildenafil Citrate (Viagra)

1/2019	Sildenafil treatment of vascular dementia in aged rats.
1/2016	Tadalafil Promotes the Recovery of Peripheral Neuropathy in Type II Diabetic Mice.
1/2016	MicroRNA 146a locally mediates distal axonal growth of dorsal root ganglia neurons under high glucose and sildenafil conditions.
1/2015	Sildenafil ameliorates long term peripheral neuropathy in type II diabetic mice.
12/2011	Longitudinal magnetic resonance imaging of sildenafil treatment of embolic stroke in aged rats.
9/2009	Sildenafil treatment of subacute ischemic stroke: a safety study at 25-mg daily for 2 weeks.
8/2008	Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats.
5/2008	Angiogenesis detected after embolic stroke in rat brain using magnetic resonance T2*WI.
2/2007	Angiogenesis and improved cerebral blood flow in the ischemic boundary area detected by MRI after administration of sildenafil to rats with embolic stroke.
11/2006	Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke.

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Michael Chopp Research Topics

Disease

216	Stroke (Strokes) 01/2022 - 01/2002
61	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2021 - 04/2002
61	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2019 - 01/2002
41	Embolic Stroke 01/2021 - 04/2002
32	Infarction (Infarctions) 01/2020 - 02/2002
31	Neoplasms (Cancer) 02/2021 - 06/2004
26	Glioma (Gliomas) 12/2016 - 05/2006
25	Ischemic Stroke 10/2021 - 01/2004
23	Ischemia 01/2021 - 01/2002
20	Brain Ischemia (Cerebral Ischemia) 01/2020 - 02/2002
16	Peripheral Nervous System Diseases (PNS Diseases) 01/2021 - 12/2012
11	Thrombosis (Thrombus) 01/2021 - 06/2003
11	Cerebral Hemorrhage 01/2019 - 02/2003
11	Brain Neoplasms (Brain Tumor) 04/2016 - 08/2005
10	Inflammation (Inflammations) 01/2021 - 11/2005
10	Brain Injuries (Brain Injury) 01/2017 - 02/2003
8	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2022 - 01/2008
8	Cognitive Dysfunction 01/2022 - 01/2019
8	Demyelinating Diseases (Demyelinating Disease) 01/2022 - 09/2005
8	Neuroinflammatory Diseases 01/2022 - 01/2016
8	Glioblastoma (Glioblastoma Multiforme) 12/2016 - 05/2006
7	Body Weight (Weight, Body) 01/2022 - 09/2008
7	Intracranial Hemorrhages (Intracranial Hemorrhage) 11/2016 - 11/2004
6	Hemorrhage 01/2022 - 07/2004
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 11/2010
6	Wounds and Injuries (Trauma) 01/2017 - 07/2003
5	Fibrosis (Cirrhosis) 01/2021 - 01/2018
5	Central Nervous System Diseases (CNS Diseases) 01/2020 - 01/2006
4	Hypoxia (Hypoxemia) 01/2020 - 04/2008
4	Closed Head Injuries 01/2019 - 06/2013
4	Gliosis 01/2019 - 02/2005
4	Diabetes Mellitus 06/2018 - 02/2011
4	Type 2 Diabetes Mellitus (MODY) 01/2017 - 07/2011
4	Gliosarcoma 12/2016 - 11/2006

Drug/Important Bio-Agent (IBA)

36	Tissue Plasminogen Activator (Alteplase)FDA Link 12/2019 - 08/2002
30	Therapeutic UsesIBA 02/2021 - 02/2003
29	MicroRNAs (MicroRNA)IBA 01/2021 - 10/2010
27	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2003
24	Neuroprotective AgentsIBA 01/2022 - 07/2003
23	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2018 - 02/2002
22	Erythropoietin FDA Link 05/2012 - 07/2004
21	Simvastatin (Zocor)FDA LinkGeneric 01/2014 - 06/2003
21	Atorvastatin (Lipitor)FDA Link 05/2013 - 06/2003
19	Phosphates (Orthophosphate)IBA 01/2021 - 09/2003
17	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2013 - 06/2003
16	Bromodeoxyuridine (BrdU)IBA 01/2022 - 01/2002
15	Sildenafil Citrate (Viagra)FDA Link 01/2019 - 11/2002
14	Peptides (Polypeptides)IBA 01/2022 - 11/2010
11	cerebrolysinIBA 01/2021 - 11/2010
11	ThymosinIBA 10/2019 - 01/2011
11	FibrinIBA 08/2019 - 05/2003
10	Angiopoietin-1IBA 01/2022 - 02/2002
10	salicylhydroxamic acid (SHAM)IBA 01/2022 - 08/2007
10	Phosphodiesterase 5 InhibitorsIBA 01/2019 - 11/2002
10	SynaptophysinIBA 07/2013 - 06/2003
9	Oxygen (Dioxygen)IBA 01/2019 - 05/2006
9	Nerve Growth Factors (Neurotrophins)IBA 01/2016 - 12/2002
9	CollagenIBA 05/2014 - 07/2006
9	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2012 - 02/2002
8	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2013 - 02/2005
8	1-phenyl-3,3-dimethyltriazene (PDT)IBA 11/2011 - 06/2004
7	Amyloid (Amyloid Fibrils)IBA 01/2022 - 02/2011
7	Pharmaceutical PreparationsIBA 02/2021 - 11/2002
7	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 06/2006
7	von Willebrand FactorIBA 01/2013 - 02/2002
6	Myelin Basic ProteinIBA 01/2022 - 08/2012
6	CytokinesIBA 01/2022 - 12/2006
6	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 06/2021 - 03/2005
6	NAD (NADH)IBA 01/2021 - 12/2017
6	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2016 - 11/2002
6	Niacin (Nicotinic Acid)FDA LinkGeneric 10/2011 - 07/2007
6	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 09/2010 - 04/2002
5	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2022 - 07/2002
5	Blood Glucose (Blood Sugar)IBA 01/2021 - 01/2015
5	CholesterolIBA 10/2018 - 02/2008
5	Matrix Metalloproteinase 9 (Gelatinase B)IBA 06/2018 - 11/2005
5	HDL LipoproteinsIBA 01/2016 - 11/2008
5	Streptozocin (Streptozotocin)FDA Link 01/2016 - 06/2008
5	EnzymesIBA 01/2015 - 07/2002
5	Glial Fibrillary Acidic ProteinIBA 12/2014 - 01/2002
5	Messenger RNA (mRNA)IBA 02/2013 - 04/2002
5	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 05/2011 - 08/2007
5	Nitric Oxide DonorsIBA 04/2010 - 04/2004
5	2,2'- (hydroxynitrosohydrazono)bis- ethanamineIBA 01/2009 - 02/2003
5	Coenzyme A (CoA)IBA 11/2005 - 07/2004
4	LipidsIBA 12/2020 - 12/2009
4	Plasminogen Activator Inhibitor 1IBA 12/2019 - 02/2010
4	Neutralizing AntibodiesIBA 10/2019 - 07/2004
4	Gadolinium DTPA (Magnevist)FDA Link 04/2017 - 08/2002
4	Liver X ReceptorsIBA 01/2017 - 01/2010
4	Histone Deacetylases (Histone Deacetylase)IBA 01/2016 - 11/2014

Therapy/Procedure

81	Therapeutics 01/2022 - 02/2003
18	Transplantation 01/2019 - 07/2002
14	Intravenous Administration 01/2020 - 01/2002
14	Thrombolytic Therapy 04/2015 - 06/2003
13	Aftercare (After-Treatment) 05/2014 - 04/2004
12	Lasers (Laser) 03/2011 - 02/2003
11	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2018 - 02/2003
8	Photochemotherapy (Photodynamic Therapy) 11/2011 - 06/2004
4	Thrombectomy 01/2021 - 01/2018